Active control of arousal by a locus coeruleus GABAergic circuit
نویسندگان
چکیده
منابع مشابه
Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal
Mood, motivation, attention, and arousal are behavioral states having a profound impact on cognition. Behavioral states are mediated though the peripheral nervous system and neuromodulatory systems in the brainstem. The noradrenergic nucleus locus coeruleus is activated in parallel with the autonomic system in response to biological imperatives. These responses can be spontaneous, to unexpected...
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The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role in a variety of behaviors is an important target of pharmacological intervention to several neurological disorders. Although GABA is the major inhibitory neurotransmitter of LC neurons, the modulation of LC neuronal firing activity by local GABAergic interneurons remains poorly understood with respect to ...
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The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combinati...
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34 Recent models posit that bursts of locus coeruleus (LC) activity amplify neural gain, such that 35 limited attention and encoding resources focus even more on prioritized mental representations 36 under arousal. Here, we tested this hypothesis in human males and females using functional 37 magnetic resonance imaging (fMRI), neuromelanin MRI, and pupil dilation, a biomarker of 38 arousal and ...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2019
ISSN: 1097-6256,1546-1726
DOI: 10.1038/s41593-018-0305-z